个人简介
新葡萄8883官网AMG教授，博士生导师。主要从事生物酶及均相催化反应机理的理论计算研究，主持国家自然科学基金4项，参加“973”计划项目课题1项。曾获得中国国家留学基金管理委员会颁发的“2008年度国家优秀自费留学生奖”，入选2015年度北京市“科技新星计划”。在催化反应机理理论和应用研究方面开展了系统的研究工作，已在J. Am. Chem. Soc.、Angew. Chem.、ACS Catalysis、J. Catalysis、Chem. -Eur. J.、J. Chem. Theory Comput.等期刊上发表SCI收录论文80余篇。
Professor and Ph.D. supervisor at Beijing Institute of Technology. Engaged in theoretical and computational research on the mechanisms of enzymatic and homogeneous catalytic reactions. Principal investigator for 4 National Natural Science Foundation projects and participated in one project under the "973" Program. Awarded the "Chinese Government Award for Outstanding Self-Financed Students Abroad" by the China Scholarship Council in 2008 and selected for the "Beijing Nova Program" in 2015. Published over 80 SCI-indexed papers in journals such as J. Am. Chem. Soc., Angew. Chem., ACS Catalysis, J. Catalysis, Chem. -Eur. J., J. Chem. Theory Comput.
研究领域和方向
生物酶与均相催化反应机理的理论研究 Theoretical research on the mechanisms of enzymatic and homogeneous catalytic reactions
教育背景
2005/11 – 2009/02，瑞典皇家工学院，生物技术学院，“生物技术”博士 2004/09 – 2008/01，北京师范大学，化学学院，“物理化学”博士 2001/09 – 2004/07，北京师范大学，化学系，“分析化学”硕士 1997/09 – 2001/07，北京师范大学，化学系，“化学教育”学士 Nov 2005 - Feb 2009: Ph.D. in Biotechnology, Royal Institute of Technology, Sweden Sep 2004 - Jan 2008: Ph.D. in Physical Chemistry, Beijing Normal University, China Sep 2001 - Jul 2004: M.S. in Analytical Chemistry, Beijing Normal University, China Sep 1997 - Jul 2001: B.S. in Chemical Education, Beijing Normal University, China
工作履历
2012/07 – 至今，新葡萄8883官网AMG，新葡萄8883官网AMG，教授 2010/10 – 2012/07，新葡萄8883官网AMG，化学学院，副教授 2009/04 – 2010/09，瑞典斯得哥尔摩大学，物理系，博士后 Jul 2012 – Present: Professor, School of Chemistry and Chemical Engineering, Beijing Institute of Technology Oct 2010 - Jul 2012: Associate Professor, School of Chemistry, Beijing Institute of Technology Apr 2009 - Sep 2010: Postdoctoral Researcher, Department of Physics, Stockholm University, Sweden
研究成果
发表论文/Publications： More publications can be found in the link: https://www.researchgate.net/scientific-contributions/Shi-Lu-Chen-39159784 [1]Rui-Ning Li and Shi-Lu Chen*, Mechanistic Insights into the N-Hydroxylations Catalyzed by the Binuclear Iron Domain of SznF Enzyme: Key Piece in the Synthesis of Streptozotocin, Chemistry – A European Journal, 2024, e202303845. [2]Han-Xiao Wu and Shi-Lu Chen*, Enzymatic C-S bond cleavage: Mechanism for the conversion of methanesulfonate to sulfite by flavin-dependent MsuD monooxygenase, Chemical Physics, 2024, 576, 112112. [3]Ying Wang and Shi-Lu Chen*, Mechanism for the synthesis of medium-chain 1-alkenes from fatty acids catalyzed by binuclear iron UndA decarboxylase, Journal of Catalysis, 2023, 420, 123–133. [4]Rui-Ning Li and Shi-Lu Chen*, Mechanism for the Halogenation and Azidation of Lysine Catalyzed by Non-heme Iron BesD Enzyme, Chemistry – An Asian Journal, 2022, 17, e202200438. [5]Ying Wang and Shi-Lu Chen*, Reaction mechanism of the PuDddK dimethylsulfoniopropionate lyase and cofactor effects of various transition metal ions, Dalton Transactions, 2022, 51, 14664-14672. [6]Jue Wu and Shi-Lu Chen*, Key Piece in the Wolfe Cycle of Methanogenesis: The S–S Bond Dissociation Conducted by Noncubane [Fe4S4] Cluster-Dependent Heterodisulfide Reductase, ACS Catalysis, 2022, 12, 2606–2622. [7]Jian Liu, Yu Hong, Yin-Ling Liu, Jing-Ying Tan, Hao-Miao Liu, Gang-Liang Dai, Shi-Lu Chen*, Ting Liu, Jin-Heng Li*, and Shi Tang*, Nickel-Catalyzed Radical Heck-Type C(sp3)–C(sp2) Coupling Cascades Enabled by Bromoalkane-Directed 1,4-Aryl Shift: Access to Olefinated Arylalanines, Organic Letters, 2022, 24, 8192−8196. [8]Jing-Xuan Su and Shi-Lu Chen*, A Key Piece in the Global N-cycle: The N-N Bond Formation Presented by Heme-dependent Hydrazine Synthase, ACS Catalysis, 2021, 11, 6489−6498. [9]Hui Yang and Shi-Lu Chen*, Enzymatic N-N bond formation: Mechanism for the N-nitroso synthesis catalyzed by non-heme iron SznF Enzyme, Journal of Catalysis, 2021, 398, 44–53. [10]Jue Wu and Shi-Lu Chen*, Handling methane: a Ni(I) F430-like cofactor derived from VB12 is active in methyl-coenzyme M reductase, Chemical Communications, 2021, 57, 476-479. [11]Chuang Song, Jupeng Chen, Zhijie Fu, Li Yan, Feng Gao, Qingbin Cao, He Li, Xiangqian Yan, Shilu Chen*, Shaowen Zhang, and Xiaofang Li*, Syndiospecific Polymerization of o-Methoxystyrene and Its Silyloxy or Fluorine-Substituted Derivatives by HNC-Ligated Scandium Catalysts: Synthesis of Ultrahigh-Molecular-Weight Functionalized Polymers, Macromolecules, 2021, 54, 10838–10849. [12]Tuemay Abadi Belay, Jupeng Chen, Huan Xu, Shaowen Zhang, Shilu Chen*, and Xiaofang Li*, Functionalization Methodology for Synthesis of Silane-End-Functionalized Linear and Star Poly(aryl isocyanide)s by Combination of Cationic Polymerization and Hydrosilylation Reaction, Macromolecules, 2021, 54, 19, 9007–9018. [13]Jing Dong, Xiangrong Sun, Ni Zhen, Zhen Li, Dan Liu, Bo Zou, Qipu Dai, Yingnan Chi*, Shilu Chen*, Josep M. Poblet, Changwen Hu*, Oxidative detoxification of nerve agent VX simulant by polyoxoniobate: Experimental and theoretical insights, Journal of Catalysis, 2021, 394, 83-93. [14]Shuo-Qi Sun and Shi-Lu Chen*, An Unprecedented Ring-Contraction Mechanism in Cobalamin-Dependent Radical S‑Adenosylmethionine Enzymes, J. Phys. Chem. Letters, 2020, 11, 6812-6818. [15]Shi-Lu Chen* and Per E. M. Siegbahn* Insights into the Chemical Reactivity in Acetyl-CoA Synthase, Inorg. Chem., 2020, 59, 15167−15179.