个人简介
学术兼职
中国微生物学会分子微生物学及生物工程专业委员会委员
《生物工程学报》期刊编委
《合成生物学》期刊编委
荣誉奖励
第五届中国科协“青年人才托举工程”
研究领域和方向
以天然产物、生物材料等化合物的微生物合成为研究目标，变革传统生产模式，利用代谢工程、合成生物学、酶工程等手段，构建微生物细胞工厂，解决生物合成的关键科学问题，提高生产效率，旨在实现上述高附加值产品的绿色生物制造，推动工业化生产。主要研究包括： 1. 解析天然产物在微生物中的合成途径，实现新化合物的微生物合成 2. 开发高效基因组装和基因组编辑技术 3. 代谢途径构建与调控 4. 开发针对特定化合物的底盘细胞改造技术，构建高效微生物细胞工厂 5. 生物材料的微生物生产
教育背景
2010/09-2015/07：清华大学，生命科学学院，理学博士 2006/09-2010/06：山东大学，生命科学学院，理学学士
工作履历
2018/05-至今： 新葡萄8883官网AMG，新葡萄8883官网AMG，特别研究员 2016/10-2017/11：美国麻省理工学院，化学工程系，博士后 2015/07-2018/04：新葡萄8883官网AMG，化学工程与技术，师资博士后
研究成果
主持国家自然科学基金等国家级项目3项、国家重点研发计划子课题2项；参与国家自然科学基金项目、973项目等4项。迄今在Metabolic Engineering, ACS Catalysis, Trends in Biotechnology, Biotechnology Advances等国内外本领域高水平期刊发表学术论文30余篇，获授权发明专利 4项。参编出版《合成生物学》教材，参与出版学术专著4部。 主持科研项目 1. 酵母合成三萜化合物关键酶的量效关系与协同调控，国家自然科学基金面上项目，2021.01-2024.12，主持 2. 合成植物天然产物的微生物细胞工厂构建及应用示范，国家重点研发计划，2019.07-2024.06，子课题负责人 3. 新天然与人工产物的定向挖掘和高效合成的平台技术，国家重点研发计划，2020.01-2024.12，子课题负责人 4. 中国科协“青年人才托举工程”，2019-2022，主持 5. 酵母生产五环三萜类化合物的胞外转运与合成强化，国家自然科学基金青年基金，2017.01-2019.12，主持 6. 微生物多层级联基因开关的设计及其生长控制，中国博士后科学基金特别资助，2016.05-2018.05，主持 7. β-香树脂醇在酿酒酵母中的胞外转运与合成强化，中国博士后科学基金面上项目一等资助， 2015.09-2017.07，主持 代表性论文 1. Yu Yuan, Rasool Aamir, Liu Haoran, Lv Bo, Chang Pengcheng, Song Hao, Wang Ying*, Li Chun*. Engineering Saccharomyces cerevisiae for High Yield Production of α-amyrin via Synergistic Remodeling of α-amyrin Synthase and Expanding the Storage Pool. Metabolic Engineering, 2020, 62: 72-83 (IF=8.8) 2. Tan Dan#, Wang Ying#, Tong Yi, Chen Guo-Qiang*. Grand Challenges for Industrializing Polyhydroxyalkanoates (PHAs), Trends in Biotechnology, 2021, 39：953-963 (ESI高被引论文，IF=21.9) 3. Sun Wentao, Xue Haijie, Liu Hu, Lv Bo, Yu Yang*, Wang Ying*, Huang Meilan, Li Chun*. Controlling Chemo- and Regioselectivity of a Plant P450 in Yeast Cell toward Rare Licorice Triterpenoid Biosynthesis, ACS Catalysis, 2020, 10: 4253-4260 (IF=13.7) 4. Wang Ying, Ling Chen, Chen Yong, Jiang Xiaoran, Chen Guo-Qiang *. Microbial engineering for easy downstream processing. Biotechnology Advances, 2019, 37: 107365 (IF=17.7) 5. Zhang Xu, Lin Yina, Wu Qiong, Wang Ying*, Chen Guo-Qiang*. Synthetic Biology and Genome Editing Tools for Improving PHA Metabolic Engineering, Trends in Biotechnology, 2019, 38: 689-700 (IF=21.9) 6. Li Chenyi#, Gao Xiaopeng#, Peng Xiao, Li Jinlin, Bai Wenxin, Zhong Jiadong, He Mengchao, Xu Ke, Wang Ying*, Li Chun*, Intelligent microbial cell factory with genetic pH shooting (GPS) for cell self‑responsive base/acid regulation. Microbial Cell Factories, 2020, 19: 202 (IF=6.4) 7. Luo Yan, Jiang Yaozhu, Chen Linhao, Li Chun, Wang Ying*. Applications of protein engineering in the microbial synthesis of plant triterpenoids. Synthetic and Systems Biotechnology, 2023, 8: 20-32 (IF=4.7) 8. Zhu Ying, Zhou Chen, Wang Ying*, Li Chun*, Transporter Engineering for Microbial Manufacturing. Biotechnology Journal, 2020, 15, 1900494 (IF=5.7) 9. Alkhadrawi Adham M., Wang Ying*, Li Chun*. In-silico screening of potential target transporters for glycyrrhetinic acid (GA) via deep learning prediction of drug-target interactions. Biochemical Engineering Journal, 2022, 181:108375 (IF=4.4) 10. Alkhadrawi Adham M., Haijie Xue, Nadeem Ahmad, Akram Muhammad, Wang Ying*, Li Chun*. Molecular study on the role of vacuolar transporters in glycyrrhetinic acid production in engineered Saccharomyces cerevisiae. BBA-Biomembranes, 2022, 1864: 183890 (IF=4.0) 11. Xue Haijie, Sun Wentao, Wang Ying*, Li Chun*, Refining metabolic mass transferring for efficient biosynthesis of plant natural products in yeast. Frontiers in Bioengineering and Biotechnology, 2021, 9: 633741 (IF=6.1) 12. Wang Ying#, Chung Ahleum#, Chen Guo-Qiang*. Synthesis of medium-chain-length polyhydroxyalkanoate homopolymers, random copolymers, and block copolymers by an engineered strain of Pseudomonas entomophila. Advanced Healthcare Materials, 2017, 6: 1601017 (IF=11.1) 13. Wang Ying, Wu Hong, Jiang Xiaoran, Chen Guo-Qiang*. Engineering Escherichia coli for enhanced production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in larger cellular space. Metabolic Engineering, 2014, 25: 183-193 (IF=8.8) 14. Wang Ying#, Li Yan#, Xua Tuan, Shi Zhenyu*, Wu Qiong*. Experimental evidence for growth advantage and metabolic shift stimulated by photophosphorylation of proteorhodopsin expressed in Escherichia coli at anaerobic condition. Biotechnology and Bioengineering, 2015, 112: 947-956 (IF=4.4) 15. Wang Ying#, Yin Jin#, Chen Guo-Qiang*. Polyhydroxyalkanoates, challenges and opportunities. Current Opinion in Biotechnology, 2014, 30: 59-65 (IF=10.3)